Orthopedic regenerative medicine offers patients a nonsurgical approach to treating arthritis, tendon injuries, ligament injuries, and certain spine conditions using advanced treatments such as PRP and bone marrow concentrate. Learn who may be a candidate and what to expect during an evaluation at Texas Orthobiologics.
Not all PRP clinics in Dallas are equal — and the differences matter. I'm Dr. Don Buford, a board-certified orthopedic surgeon and President of the Interventional Orthobiologics Foundation. I've been performing regenerative medicine procedures since before most of these clinics existed, and I've trained over 2,000 physicians how to do this properly. Here's what I tell patients when they ask how to evaluate a PRP clinic.
Patients are hearing wildly different claims about peptides like BPC-157, TB-500, and GHK-Cu. Some clinics say they are legal. Others say they are banned. So what is actually true? In this article, orthopedic surgeon and regenerative medicine specialist Dr. Don Buford breaks down the real FDA regulatory landscape surrounding peptides, compounding pharmacies, enforcement policies, and what patients need to understand before considering these compounds in 2026.
Frozen shoulder is often treated as a simple shoulder problem—but that approach frequently leads to prolonged pain and slow recovery. Learn why most treatments fail and what actually works to restore motion faster.
Why try peptides like BP-157 and TB-500 for orthopedic problems when we know that high dose PRP is better?*
In 2024 a research group in Iran did a well designed and controlled trial comparing 5cc of placental derived exosomes with 5cc of normal saline. 29 Patients were followed for six months.....58 knees total. Patients got MRI scans before and after.
The result? There was no difference between the exosome knee and the normal saline knee in any measurable significant way.
More work to be done on this topic for sure.....at the very least so far no clinical science supports using these allograft derived exosomes in knee arthritis.
Texas Orthobiologics is your PRP (platelet rich plasma) expert and your stem cell (bone marrow concentrate) expert AND your orthopedic surgery expert all in one Dallas location! Don Buford, MD, as the clinic's founder and Director, is involved in the care of every patient directly and his 26+ years as a clinical researcher and orthopedic surgeon means he has broad experience in orthopedic regenerative medicine. As the two time President of the Interventional Orthobiologics Foundation and the recipient of the 2025 Lifetime Achievement Award from TOBI, Dr. Buford is widely recognized as one of the "go-to" experts in this rapidly growing field.
We serve local patients in Dallas, Highland Park, University Park, Preston Hollow, Mesquite, Rockwall, Heath, Flower Mound, Plano, McKinney, Allen, Southlake, Westlake, Irving, Grapevine, Fort Worth, Richardson, Farmer's Branch, Colleyville.
This picture shows ticket prices for an upcoming World Series game between the Dodgers and Blue Jays. For 2 people to go, it costs more than the average price for single PRP injection...even in the nosebleed bleacher seats. The game will last about 3.5 hours and other than the memories the money spent is gone that night...no ongoing daily benefits. There will be 41,500 people at this game who value this one game more than a PRP injection.
Are there any safety or placebo trials registered for the peptide BP-157?
I get this question often from clinicians and patients ask me what I mean when I say there is no human safety data.
There is no peer reviewed, publicly posted human safety data for BP–157 despite rapidly growing use spurred on by podcasts, gym talk, and social media.
Every 6 months or so I like to update my list of publications which include articles, book chapters, letters to the editor, and other references. My first co-authored paper, "The Buford Complex..." was published way back in 1994! So far in 2025, I have 4 articles/letters that have been published so far.
I stay current with the latest orthopedic and regenerative medicine research because I want my patients to have access to the best results as documented in research from around the world. Whenever I get a chance, I like to contribute and participate to this rapidly growing field within orthopedics.
